Brain Tumor Grade & Pathology (2009)

Please be aware that the expected second brain surgery is at the end of December 2020. You can learn more about why this is happening here and see the MRI outcome.

Ronaldo Del Maestro 2019.png
Dr. Rolando Del Maestro

The operation was done at the Montreal Neurological Institute, in Canada in February 2009. Dr. Rolando Del Maestro was the one who carried it out. His research is focused on surgical simulation using the NeuroTouch platform, working in cooperation with the National Research Council of Canada and multiple national and international research groups. He and his wife worked on creating the Brain Tumour Foundation of Canada.

Before Brain Surgery

fMRI & PET Scan Report (2008/2009)

The tests showed my speech to be predominantly on the LEFT with very little speech on the right. My motor and sensory areas appeared to be a substantial distance away from the lesion. The good news was: There isn’t any language function within the lesion that is intended to be cut!

The above is part of the Imaging of Cognitive Functions using functional Magnetic Resonance Imaging (fMRI) can be downloaded here

PET Scan reports can be shared with you upon request. These tests allowed the surgeon to safely “cut” the brain areas needed. It is interesting to share that my brain function had moved over time (since childhood) away from where it would typically be, and that made it safe to undertake the surgery.

During Operation

The operation took around 11 hours. I was awake during the operation (on and off) for testing. The last time they woke me up resulted in me not being able to respond to questions properly (slower word finding, and sometimes not finding the word).

Therefore, they decided to stop the operation after cutting ~92% of the targeted tumor resection.

Sample from the surgery

I have more photos of this sort, but they looked the same to me, so I decided to share only one at this stage. I can share the others upon request.

Right After Surgery

Post-surgery Report (2009)

The diagnostic was a low-grade astrocytoma (low-grade mixed glioma), WHO grade-II involving posterior left temporal lobe – MGMT promotor methylation.

There are three reports from the Montreal Neurological Institute and Hospital:

Other Neuropathology Report (2009)

The most importantly facts are that my tumor is:

I learned in 2016 that I should have checked for IDH1 mutation with a test, but I did not do it yet and I wasn’t sure if I should spend effort on that front.

Chemotherapy and Radiotherapy

Never done.

Second Opinion on Neuropathology

I sent a sample of the pathology from Canada to United Kingdom. Purpose is for Cleveland to give me their second opinion.

Their work showed that what I gave is a Low-grade oligoastrocytoma (low-grade mixed glioma), WHO grade II. That clearly is different from what Canada believed in.

The detailed report is very rich, and you can see many key information including prognosis.

Parts of their 19 page report, they said the following

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) have been implicated in tumorigenesis of gliomas. Patients with high-grade astrocytomas with IDH1 or IDH2 mutations were reported to have a better survival. IDH1 mutations were present in the majority of progressive astrocytomas. No mutations in IDH2 were found. For low grade gliomas, presence of IDH1 mutations were early events and significantly improved overall survival (median survival 48 vs. 98 months).

These results indicate that IDH1 mutations identify a subgroup of gliomas with an improved survival. Dubbink et al, Neurology Nov 24;73 1792-5, 2009
A more recent review from Germany by Ahmadi et al J Neurooncology 2012 April (Epub ahead of print) looked at 100 low grade astrocytoma patients and found no difference in overall survival or progression free survival relative to IDH1 mutation state in patients who did not receive adjuvant treatment.

While the IDH1 mutational data is still a relatively new finding and will require further investigation, the 1p19q implications have been well characterized and co-deletions of 1p19q, while not definitive for treatment modality, are prognostic which in turn might then affect the order of treatment. In general terms, if we have a low grade glioma patient that has a 1p19q deletion and we feel they need treatment, and surgery is not an option, we are more likely to treat with chemotherapy first and that treatment is usually Temozolomide. Having a low grade mixed glioma vs. a low grade astrocytoma increases the likelihood of 1p19q deletions


Mohammad Banat

Mohammad Banat

I'm an entrepreneur who founded and runs an IT company in the Middle East. However, my life took an unexpected turn after I underwent brain surgery in 2009 to remove an Oligodendroglioma in my temporal lobe.